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Orthogonal wettability and topographical gradients in a combinatorial sample format are fabricated using plasma-polymer-coated microgrooved surfaces. Preferred cell proliferation is found on specific combinations of topography and chemistry. This proof-of-concept study demonstrates the potential applications of this sample format for investigating the relationship between multiple surface properties on cellular response in a high-throughput manner.
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Yang et al. (2008) studied this question.
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