Why the study?
Increased myocardial 18F-FDG uptake on PET/CT may reflect early metabolic alterations, prompting evaluation of its role alongside myocardial strain and troponin for detecting anthracycline-induced cardiotoxicity in lymphoma patients.
Do 18F-FDG PET/CT and global longitudinal strain detect early cardiotoxicity in adult lymphoma patients receiving anthracycline therapy?
Population
55 adult lymphoma patients receiving anthracycline therapy
Comparison
Assessments at baseline, mid-therapy, and posttreatment
Design
Prospective multicenter study
Follow-up
3 months
Authors
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Myocardial 18F-FDG uptake may signal early anthracycline cardiotoxicity; hypothesis-generating and requires validation before clinical adoption.
Do 18F-FDG PET/CT and global longitudinal strain detect early cardiotoxicity in adult lymphoma patients receiving anthracycline therapy?
In lymphoma patients receiving anthracyclines, global longitudinal strain detects early subclinical cardiotoxicity, whereas increased myocardial 18F-FDG uptake on PET/CT does not correlate with ventricular dysfunction.
Becker et al. (2025) studied this question.
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