Why the study?
Does an exercise stress test increase high-sensitivity cardiac troponin T levels in patients with stable CAD compared to controls?
Does an exercise stress test increase high-sensitivity cardiac troponin T levels in patients with stable CAD compared to controls?
Exercise stress testing can elevate hs-cTNT above the 99th percentile diagnostic cut-off for myocardial infarction in a majority of patients with stable CAD, which should be considered when interpreting biomarker levels.
May confound post-stress hs-cTNT interpretation in stable CAD; leaves open need for adjusted thresholds in prospective studies.
OBJECTIVE: The aim was to assess serial measurements of high-sensitivity cardiac troponin T (hs-cTNT) post-exercise in patients with stable coronary artery disease (CAD). METHODS: Twelve patients with positive coronary angiograms (CAD positives) and 12 controls performed an exercise stress test. RESULTS: CAD positive had higher baseline and peak concentrations of hs-cTNT than controls. Significant increases in hs-cTNT were seen in both groups after exercise. In two-third of patients the peak in hs-cTNT was above the 99th percentile. CONCLUSION: hs-cTNT is higher in patients with stable coronary disease than in controls and exceeds the diagnostic cut-off value for myocardial infarction in a majority of patients with CAD after exercise.
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Raja et al. (2013) studied this question.
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