Why the study?
Do antibiotics alter the bacterial flora of the colon in patients preparing for elective surgery of the colon?
Do antibiotics alter the bacterial flora of the colon in patients preparing for elective surgery of the colon?
This paper outlines a program for intestinal antisepsis using antibiotics prior to elective colon surgery.
Provides foundational description of intestinal antisepsis; leaves open its role in current perioperative protocols amid resistance concerns.
The role of antibiotics in large bowel surgery was established by experimental studies indicating that antibiotics could protect a colonic anastomosis subjected to unusual stress. A number of different agents were studied to patients to determine which ones significantly altered the bacterial flora of the colon. Clinical studies were conducted with the agent of choice on the basis of these results. This paper describes a program for preparing patients for elective surgery of the colon.
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Isidore Cohn (1982) studied this question.
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