Heritability and Linkage Analysis for Carotid Intima-Media Thickness
Population
1390 Caribbean Hispanic subjects from 100 Dominican families from the population-based Northern Manhattan…
Design
Cohort
Authors
Discussion
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Implication
Hypothesis-generating for genetic CIMT determinants in Hispanics; leaves open replication before informing risk models.
Structured PICO
P
Population
1390 Caribbean Hispanic subjects from 100 Dominican families (848 females; mean age 46.2 years) from the population-based Northern Manhattan Study.
O
Outcome
Quantitative trait loci (QTL) for carotid intima-media thickness (CIMT) measured by high-resolution B-mode ultrasoundsurrogate
Significant quantitative trait loci for carotid intima-media thickness were identified on chromosomes 7p and 14q in a Caribbean Hispanic cohort, accounting for substantial trait heritability.
Cite This Study
Sacco et al. (2009) studied this question.