January 1, 2001The Journal of PhysiologyOpen Access

Cyclic GMP‐dependent relaxation of isolated rat renal glomeruli induced by extracellular ATP

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Why the study?

Does extracellular ATP induce relaxation in isolated rat renal glomeruli?

Population

Isolated rat renal glomeruli precontracted with angiotensin II

Design

Preclinical

Authors

MJMaciej JankowskiGdańsk Medical University MSM Szczepańska-KonkelGdańsk Medical University LKLeszek KalinowskiUniversity of Illinois Urbana-Champaign

Discussion

Member takes

Implication

ATP-mediated glomerular relaxation in rats warrants no clinical change; leaves open purinergic GFR regulation in vivo or humans.

Structured PICO

Does extracellular ATP induce relaxation in isolated rat renal glomeruli?

Population

Isolated rat renal glomeruli precontracted with angiotensin II

Intervention

Extracellular ATP and its analogues (ADP, AMP, UTP, 2-methylthio-ATP, beta,gamma-methylene-ATP, adenosine)

Outcome

Relaxation of glomeruli based on changes of glomerular [3H]inulin space (GIS)surrogate

Extracellular ATP relaxes isolated rat renal glomeruli via P2Y receptor activation, endothelial NOS, and soluble guanylyl cyclase, suggesting a role in regulating glomerular filtration rate.

Cite This Study

Jankowski et al. (2001) studied this question.

synapsesocial.com/papers/6a908c77fdaee66aea8413b5 https://doi.org/10.1111/j.1469-7793.2001.0123m.x

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Cyclic GMP‐dependent relaxation of isolated rat renal glomeruli induced by extracellular ATP

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Cyclic GMP‐dependent relaxation of isolated rat renal glomeruli induced by extracellular ATP

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Also Consider