Why the study?
Does ticlopidine enhance IL-1beta-stimulated nitric oxide production in cultured rat vascular smooth muscle cells?
Population
Cultured rat vascular smooth muscle cells (VSMC)
Comparison
Ticlopidine added to interleukin-1beta (IL-1beta) vs Interleukin-1beta (IL-1beta) alone
Design
Preclinical
Authors
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Hypothesis-generating in rat cells; leaves open any clinical hypotensive relevance in humans.
Does ticlopidine enhance IL-1beta-stimulated nitric oxide production in cultured rat vascular smooth muscle cells?
Ticlopidine enhances IL-1beta-induced nitric oxide production via cAMP and protein kinase A activation in rat vascular smooth muscle cells, providing a potential mechanism for its hypotensive effect in hemodialysis patients.
Inoue et al. (2002) studied this question.
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