Why the study?
Does oral ticlopidine inhibit ADP-induced platelet aggregation in rabbits with experimental hypercholesterolemia?
Population
Rabbits with experimental hypercholesterolemia and normocholesterolemic controls
Comparison
Oral ticlopidine (100 mg/kg x day) vs Normocholesterolemic controls (standard diet)
Design
Preclinical
Follow-up
4 months
Authors
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May attenuate ticlopidine efficacy in hypercholesterolemia; leaves open human relevance and requires clinical validation.
Does oral ticlopidine inhibit ADP-induced platelet aggregation in rabbits with experimental hypercholesterolemia?
Experimental hypercholesterolemia in rabbits attenuates the antiplatelet efficacy of ticlopidine, likely due to stimulation of thromboxane formation.
Hohlfeld et al. (1994) studied this question.
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