In the whirlwind of cloning, mutagenesis, and, suddenly, structure that the ion channel field has been riding for the past 15 yr, it is easy to forget that we still don't have a satisfactory view of that most basic task carried out by these proteins: ion permeation. The diffusion of ions through the
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Christopher Miller (1999) studied this question.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: