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An efficient resolution process using N -methyl glucamine (meglumine) which directly provides ( S )-etodolac as the meglumine salt is described. This salt is also a dosage form with improved absorption characteristics. The off-isomer is efficiently racemised via the ester, prepared by mild esterification, followed by hydrolysis affording rac- etodolac suitable for recycling.
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WOODS et al. (2000) studied this question.
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