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The palladium-mediated intramolecular coupling of amino-tethered vinyl halides and ketone enolates is a useful methodology for the synthesis of nitrogen heterocycles and constitutes a new synthetic entry to the 2-azabicyclo[3.3.1]nonane framework. A study about the reaction conditions and the scope of the process is reported.
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Solé et al. (2000) studied this question.
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