Answers are grounded in this paper and cite their sources.
The synthesis of (+/-)-histrionicotoxin has been achieved in just nine steps using a two-directional synthesis strategy. Key reactions include a two-directional cross-metathesis, a tandem oxime formation/Michael addition/1,4-prototopic shift/[3 + 2]-cycloaddition cascade, a selective Z,Z-bisenyne formation, and a one-pot N-O and bischloroacetylene reduction.
No takes yet. Share an insight, caveat, or question.
Karatholuvhu et al. (2006) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: