Aziridinyl Anions: Generation, Reactivity, and Use in Modern Synthetic Chemistry

The high synthetic usefulness of aziridines has been often to their electrophilic nature, undergoing nucleophilic -opening reactions, as usually taught in organic chemistry . The aim of this review is to highlight other aspects aziridine reactivity, now well out of their infancy. Indeed, can be easily metalated, generating the corresponding anions, which could act as nucleophiles the three-membered ring functionality intact or, under circumstances, as carbenoids thus disclosing an reactional scenery. Even if the reactivity of anions closely mirrors that of the corresponding anions, the investigations of the last 10 years that additional factors should be taken into when the generation of metalated aziridines concern.