Synthesis and reactions of esters of N‐hydroxyphthalimide and N‐protected amino acids

Esters can be prepared from N‐hydroxyphthalimide and N‐carbobenzoxy‐ or N‐phthaloyl‐amino acids using dicyclohexylcarbodi‐imide as condensing agent. The compounds are suitable for the stepwise synthesis of peptides without racemization. With methanol the N‐hydroxyphthalimide ester of N‐phthaloylglycine can be converted into the methyl ester of N‐phthaloylglycine.