One pot synthesis of tetrasubstituted thiophenes: [3 + 2] annulation strategy

This is the authors' abstract. We don't add key points for this paper.

A simple, efficient and economical synthesis of dimethyl 3-amino-5-(2-oxo-2-arylethyl)thiophene-2,4-dicarboxylates has been reported by ring opening of methyl 3-amino-6-aryl-4-oxo-4 H -thieno[3,2- c ]pyran-2-carboxylates by alkoxide ions.