A facile, general synthesis for a number of 5‐substituted‐1‐methyluracils and cytosine which is suitable for the preparation of micro‐quantities is reported. In contrast to other methods, the 5‐substituent plays no role in determining the position of alkylation. 1‐Methyl‐5‐hydroxymethyluracil and 1‐methyl‐5‐formyluracil have also been synthesized by an alternate route.
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Sakai et al. (1968) studied this question.
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