Association between female-specific reproductive factors and leukocyte telomere length

Gaojie Fan; Qing Liu; Jianing Bi; Xiya Qin; Qing Fang; Youjie Wang; Lulu Song

doi:10.1093/humrep/dead176

August 25, 2023Human Reproduction

Association between female-specific reproductive factors and leukocyte telomere length

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Key Points

To examine the associations between female-specific reproductive factors and cellular aging as measured by leukocyte telomere length.
Analyzed cross-sectional data from 224,965 women aged 40–69 years enrolled in the UK Biobank between 2006 and 2010.
Assessed self-reported reproductive factors including age at menarche, natural menopause, parity, age at first birth, pregnancy loss, oral contraceptive use, and hormone replacement therapy.
Measured leukocyte telomere length using a validated polymerase chain reaction assay and analyzed associations using multivariable linear regression and restricted cubic spline models.
Significantly shorter telomeres were observed with early menarche (<12 years; percent change: -1.29%, 95% CI: -2.32% to -0.26%), early menopause (<45 years; percent change: -7.18%, 95% CI: -8.87% to -5.45%), and short reproductive lifespan (<30 years; percent change: -6.10%, 95% CI: -8.14% to -4.01%).
Shorter telomeres were also linked to multiparity (percent change: -3.38%, 95% CI: -4.38% to -2.37%), first birth before age 20 (percent change: -4.46%, 95% CI: -6.00% to -2.90%), oral contraceptive use (percent change: -1.10%, 95% CI: -2.18% to -0.02%), and hormone replacement therapy (percent change: -3.72%, 95% CI: -4.63% to -2.80%).
No significant associations were observed for miscarriage or stillbirth, while nonlinear relationships were confirmed for menarche, menopause, reproductive lifespan, and age at first birth (Pnonlinear < 0.05).

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Implication

Population-based study reveals shorter leukocyte telomeres in women with earlier reproductive milestones, indicating accelerated biological aging linked to hormonal events.

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Fan et al. (2023) studied this question.

synapsesocial.com/papers/6a909b54d68f3313dd842cee https://doi.org/10.1093/humrep/dead176

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Association between female-specific reproductive factors and leukocyte telomere length

Key Points

No abstract yet

Implication

Discussion

Cite This Study

Association between female-specific reproductive factors and leukocyte telomere length

Key Points

No abstract yet

Implication

Discussion

Cite This Study

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