Retention gaps with different polarity treatments were evaluated for reversed phase solvents. Aminopropyl‐ and cyanopropyl‐deactivated retention gaps showed the best results for methanol‐water mixtures. A reversed phase packed fused silica capillary LC column is connected on‐line with a capillary gas chromatography column. The combination was used for the analysis of diazepam in urine. Volume overloading on packed fused silica columns without loss of too much efficiency was demonstrated for propranolol.
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Duquet et al. (1988) studied this question.
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