Why the study?
What is the multiple-dose pharmacokinetic profile of intravenous imipenem-cilastatin in normal volunteers?
Population
6 normal volunteers
Design
Other
Follow-up
40 doses (every 6 hours)
Authors
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Supports q6h dosing in healthy volunteers; leaves open efficacy confirmation in infected or special populations.
What is the multiple-dose pharmacokinetic profile of intravenous imipenem-cilastatin in normal volunteers?
Imipenem-cilastatin administered at 1,000 mg every 6 hours maintains concentrations above the MIC for most pathogens despite short elimination half-lives.
Drusano et al. (1984) studied this question.
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