Controlled release of vesicle-entrapped substances in response to changes in environmental conditions may provide a basis for new technologies in pharmaceutics, in imaging, in sensing, or in medical diagnostics. We describe in this paper a fundamentally new method of producing pH-sensitive vesicles from pH-insensitive amphiphiles, a method that consists of complexation of the amphiphile with a pH-sensitive polyelectrolyte.
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Tirrell et al. (1985) studied this question.
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