Key result
Pregnancy-associated SCAD is managed conservatively in ~56% of cases despite high-risk postpartum presentation.
Why the study?
Pregnancy-associated spontaneous coronary artery dissection (P-SCAD) is an important but understudied cause of myocardial infarction and maternal death, with limited data on clinical presentation, management, and pregnancy outcomes after SCAD.
What are the clinical presentation, management, and outcomes of pregnancy-associated spontaneous coronary artery dissection?
Observational (n=123)
Yes
What are the clinical presentation, management, and outcomes of pregnancy-associated spontaneous coronary artery dissection?
Captured external expert commentary on this paper, strongest first. Original sources are linked where available.
“It's very likely to be related to those changes in how the vascular wall is made up as a consequence of those very precipitous changes in female sex hormones that occur after delivery.”
“a fairly similar and not insubstantial risk”
P-SCAD is a high-risk condition occurring mostly postpartum, but conservative management is often feasible and subsequent pregnancies have a modest recurrence risk.
Contains fulltext : 283520.pdf (Publisher’s version ) (Open Access)
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Chan et al. (2022) conducted an observational in Pregnancy-associated spontaneous coronary artery dissection (P-SCAD) (n=123). Pregnancy-associated spontaneous coronary artery dissection was evaluated on Clinical presentation, management, and outcomes of pregnancy-associated SCAD. Pregnancy-associated SCAD predominantly occurred postpartum with high-risk features, though 56% were managed conservatively, and subsequent pregnancies carried an 8% risk of major adverse cardiovascular events.
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