May 1, 2007Journal of Veterinary Internal MedicineOpen Access

A Novel Mutation of the CLCN1 Gene Associated with Myotonia Hereditaria in an Australian Cattle Dog

View Full Paper

Ask AI

Bookmark

Population

A pure-bred Australian Cattle Dog from Ontario, Canada, with generalized muscle stiffness and hypertrophy

Design

Case_report

Authors

DFDaniel F. FinniganUniversity of Guelph WHW. J. Brad HannaUniversity of Cologne RPRoberto PomaFederico Villarreal National University

Discussion

Member takes

Implication

First CLCN1 mutation reported in myotonic Australian Cattle Dog; extends canine myotonia genetics but remains hypothesis-generating.

Structured PICO

Population

A pure-bred Australian Cattle Dog from Ontario, Canada, with generalized muscle stiffness and hypertrophy (n=1)

Intervention

Genetic analysis of a muscle biopsy

Outcome

Identification of a mutation in the CLCN1 genesurrogate

This report describes the first genetically characterized case of myotonia in an Australian Cattle Dog, caused by a single base insertion in the CLCN1 gene.

Cite This Study

Finnigan et al. (2007) studied this question.

synapsesocial.com/papers/6a90d1bd01e1e58c2c70f471 https://doi.org/10.1111/j.1939-1676.2007.tb02990.x

View Full Paper

Ask AI

Bookmark

A Novel Mutation of the CLCN1 Gene Associated with Myotonia Hereditaria in an Australian Cattle Dog

Discussion

Member takes

Implication

Structured PICO

Cite This Study

A Novel Mutation of the CLCN1 Gene Associated with Myotonia Hereditaria in an Australian Cattle Dog

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider