What question did this study set out to answer?

To evaluate the specific pharmacological actions of platelet-activating factor (Paf-acether) on coronary blood flow and cardiac contractility in isolated heart preparations.

September 1, 1983British Journal of PharmacologyOpen Access

The actions of Paf‐acether (platelet‐activating factor) on guinea‐pig isolated heart preparations

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Why the study?

Does Paf-acether reduce coronary flow and contractile force in isolated guinea-pig heart preparations?

Population

Isolated heart preparations from normal guinea-pigs

Comparison

Paf-acether (platelet-activating factor) vs Non-acetylated Paf-acether analogue, the…

Design

Preclinical

Authors

JBJacques BenvenisteUniversité Paris-Sud CBC BoulletUniversité Paris-Sud CBCharles BrinkHôpital Marie Lannelongue

Discussion

Member takes

Implication

Paf-acether effects in isolated hearts warrant no clinical action; leaves open in vivo relevance or human translation.

Key Points

To evaluate the specific pharmacological actions of platelet-activating factor (Paf-acether) on coronary blood flow and cardiac contractility in isolated heart preparations.
Administered Paf-acether in varying concentrations to isolated heart preparations from normal guinea-pigs.
Tested cardiac responses in the presence of atropine to assess cholinergic receptor involvement.
Evaluated structural specificity using the non-acetylated analogue 2-lyso Paf-acether, its enantiomer, and 1,alpha-lysophosphatidylcholine palmitoyl.
Paf-acether caused significant, concentration-dependent reductions in both coronary flow and myocardial contractile force.
High concentrations of Paf-acether reduced cardiac parameters equally well in the presence of atropine.
Related phospholipid analogues, including 2-lyso Paf-acether and 1,alpha-lysophosphatidylcholine palmitoyl, failed to alter coronary flow or contractile force.

Structured PICO

Does Paf-acether reduce coronary flow and contractile force in isolated guinea-pig heart preparations?

Population

Isolated heart preparations from normal guinea-pigs

Intervention

Paf-acether (platelet-activating factor)

Comparator

Non-acetylated Paf-acether analogue (2-lyso Paf-acether), the enantiomer, and 1, alpha-lysophosphatidylcholine palmitoyl

Outcome

Coronary flow and contractile forcesurrogate

Paf-acether exerts a potent, specific, concentration-dependent reduction in coronary flow and contractile force in isolated guinea-pig hearts.

Cite This Study

Benveniste et al. (1983) studied this question.

synapsesocial.com/papers/6a90d6791a4f16208192cb4a https://doi.org/10.1111/j.1476-5381.1983.tb11052.x

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The actions of Paf‐acether (platelet‐activating factor) on guinea‐pig isolated heart preparations

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

The actions of Paf‐acether (platelet‐activating factor) on guinea‐pig isolated heart preparations

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider