Association between age at menarche and infertility in Tabari cohort population: a population-based case-control study

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OBJECTIVE: There are conflicting results regarding the association between age at menarche (AAM) and infertility in different nations. Thus, this study aimed to determine this relationship in a cohort of northern Iranian population (Tabari Cohort Study). RESULTS: The mean menarche age for the case and control groups was 13.48 ± 1.63 and 13.67 ± 1.72, respectively (P: 0.060). The rate of infertility in women of early, normative, and late menarche were 56.3%, 50.4% and 30.4% respectively. The results of the adjusted logistic regression analysis showed that women with early AAM (OR: 3.36, 95% CI: 1.48-7.63, P: 0.004) and normative AAM (OR: 2.90, 95% CI: 1.42-5.90, P: 0.003) had higher odds for infertility compared to females with late menarche with a trend toward higher risk in earlier AAM.