Why the study?
Previous comparison of programmed intermittent epidural bolus and patient-controlled epidural analgesia was limited by unequal bolus volumes (10 ml vs 5 ml).
Does patient-controlled epidural analgesia with 10 ml boluses reduce breakthrough pain and analgesic intake compared to programmed intermittent epidural bolus in nulliparous women in labour?
Population
360 nulliparous women
Comparison
10 ml patient-controlled epidural analgesia vs 10 ml programmed intermittent epidural bolus supplemented by 5 ml patient-controlled boluses
Design
Randomised, multicentre non-inferiority trial
Authors
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PIEB improves labor analgesia quality over PCEA; extends RCT evidence favoring programmed intermittent boluses for epidural maintenance.
Does patient-controlled epidural analgesia with 10 ml boluses reduce breakthrough pain and analgesic intake compared to programmed intermittent epidural bolus in nulliparous women in labour?
Patient-controlled epidural analgesia with 10 ml boluses is non-inferior to programmed intermittent epidural bolus for breakthrough pain and superior for reducing local anesthetic consumption during labor.
Roofthooft et al. (2023) studied this question.
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