Why the study?
Does chemotherapy cause histologic changes in the oral mucosa in patients with extra-oral malignancies?
Does chemotherapy cause histologic changes in the oral mucosa in patients with extra-oral malignancies?
The study investigates histologic changes in the oral mucosa related to pharmacological toxicity of chemotherapeutic agents.
Suggests possible chemotherapy-related oral mucosal changes; hypothesis-generating and should not change practice.
Histologic changes in the oral mucosa of 120 specimens from 30 patients who had received chemotherapy for a variety of extra-oral malignancies were studied in an attempt to relate the phenomena to pharmacological toxicity of the chemotherapeutic agents and other factors.
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Lockhart et al. (1981) studied this question.
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