Amyloidosis Associated with the Nephrotic Syndrome and Transfusion Reactions in a Haemophiliac

Summary. It is suggested that the immunological response in a severe haemophiliac to longstanding incompatible plasma infusions may have been responsible for the development of amyloidosis which culminated in the nephrotic syndrome. Serological studies showed that the patient had a circulating anti‐Gm(1) antibody, and also that possibly he was on occasions reacting violently towards the infusion of immune complexes formed between the IgG1 (Fc region) antigens, Gm(1) and ISf(1) and their antibodies. Despite the fact that there was a marked reduction in the number and severity of transfusion reactions after treatment solely with selected Gm(‐1) plasmas, there was a progressive deterioration in the patient's renal function.