EDGF, a growth factor purified from bovine retina is able to increase the rate of wound healing of rabbit corneal epithelium in a dose dependent way. Two applications a day are enough to obtain the maximum rate. The most purified preparation of EDGF is as effective as EGF or pFGF in promoting this phenomenon and allows the epithelium to reach its normal organization earlier. Excess addition of EDGF did not adversely affect the normal or healed epithelium.
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Petroutsos et al. (1984) studied this question.
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