Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
June 1, 2022Therapeutic DeliveryOpen Access

Protein-based Nanomaterials: a New Tool for Targeted Drug Delivery

View Full Paper
Ask AI
Bookmark
Share

Authors

AAAlaa A. A. AljabaliMRMeriem RezigueRARawan Alsharedeh

Discussion

Loading...

Member takes

Overview

Review reveals the utility of self-assembling protein nanomaterials in drug delivery platforms, suggesting enhanced efficacy through biodegradable, three-interface functionalization.

Key Points

  • To examine the physicochemical characteristics, functionalization strategies, and therapeutic performance of protein-based nanomaterials for targeted drug delivery.
  • Reviewed naturally derived and engineered self-assembling protein structures, including virus capsids, virus-like particles, ferritin, heat shock proteins, and chaperonins.
  • Assessed biological transport parameters, focusing on external, internal, and intersubunit interfacial modifications, cellular uptake mechanisms, release kinetics, and systemic clearance.
  • Hollow protein architectures demonstrate inherent biocompatibility, complete biodegradability, low toxicity, and optimal size profiles for efficient receptor-mediated endocytosis.
  • Tri-interface engineering allows simultaneous therapeutic cargo encapsulation within the interior cavity and cell-specific ligand attachment on external surfaces to optimize release kinetics.

Cite This Study

Aljabali et al. (2022) studied this question.

synapsesocial.com/papers/6a90e05ef61bbdbd5ac1a4bbhttps://doi.org/10.4155/tde-2021-0091
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Designing Protein-Based Nanoparticles for Therapeutic Applications2025
  2. 2Protein Nanocarriers: Targeted Theranostics for Cancer Treatment and Imaging2026
  3. 3Molecular Engineering of the Nano‐Bio Interface for Programmable and Precision Protein Delivery2026
  4. 4NANOPARTICLES AS TARGETED DRUG DELIVERY SYSTEMS: RECENT ADVANCES AND FUTURE PERSPECTIVES2026
  5. 5Therapeutic Potential of Nanomaterial-based Drug Delivery2024