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Leucin-rich glioma-inactivated protein 1 (LGI1) encephalitis is the second most common cause of autoimmune encephalitis; it is a rare and poorly recognized phenomenon. Unlike the typical presentation of LGI1 type of limbic encephalitis in regard to age (30–70 years) as well as gender (M>F), we are describing a case of an adolescent female who presented to us with psychiatric manifestations and initial insignificant neuro-imaging, which led to misdiagnosis and thus delay in her treatment. This case study highlights how the clinician must think ahead of the prevalence patterns and entertain rare possibilities in such atypical cases.
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Sikka et al. (2025) studied this question.
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