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Do substituted adenosine analogues alter systemic blood pressure, coronary blood flow, and cardiac contractility compared to adenosine in anaesthetized dogs?
Do substituted adenosine analogues alter systemic blood pressure, coronary blood flow, and cardiac contractility compared to adenosine in anaesthetized dogs?
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Substituted adenosine analogues, particularly 2-chloroadenosine, demonstrate altered potency and prolonged duration of coronary dilator activity compared to adenosine in a canine model.
The effects of adenosine on systemic blood pressure, coronary blood flow and cardiac contractility and rate were studied in anaesthetized open-thorax dogs.2. The potency and duration of action of substituted adenosine analogues were compared with that of adenosine.3. With the exception of 2-chloroadenosine, in which coronary dilator activity was enhanced, substitution in the 2-position of the adenosine molecule reduced activity.4. In all cases 2-substitution prolonged the duration of the coronary dilator activity of adenosine.5. N(6)-Methylation of adenosine and 2-chloroadenosine reduced their coronary dilator activities, but had no effect on the duration of the response.6. Comparison of the coronary dilator potencies and hypotensive activities of 2-ethylaminoadenosine and 2-methoxyadenosine indicates that these analogues have some specificity for the coronary bed.
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Angus et al. (1971) studied this question.
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