The Effect of Glucose on the Glomerular Filtration Rate in Normal Man

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Abstract.On ten occasions the renal clearances of inulin andaCr‐EDTA have been measured before, during and after hyperglycemia induced in nine normal young men. Glucose was given as a combined oral and intravenous load, so that the blood glucose concentration was elevated moderately for 2–3 hours. During the hyperglycemia there was a highly significant increase, averaging about 9%, in the inulin and61Cr‐EDTA clearances. The maximum increase in inulin clearance averaged 18% and in61Cr‐EDTA clearance, 19%. The plasma volume increased, on average, 16%. The effect of glucose loading on the glomerular filtration rate may be explained either by hemodynamic factors or by an interaction between glucose and sodium transport in the kidney.