Why the study?
Does a rapid reversed passive latex agglutination method using high-density latex particles improve the detection time of staphylococcal enterotoxins A to E compared to a customary latex agglutination test?
Does a rapid reversed passive latex agglutination method using high-density latex particles improve the detection time of staphylococcal enterotoxins A to E compared to a customary latex agglutination test?
A newly developed rapid latex agglutination test using high-density latex particles significantly reduces the incubation time for detecting staphylococcal enterotoxins A to E from 16 hours to 3 hours without compromising sensitivity or specificity.
May shorten enterotoxin detection in labs; leaves open clinical adoption pending human validation.
A rapid reversed passive latex agglutination method that uses high-density latex particles for the detection of staphylococcal enterotoxins (SE) A to E was developed. It took 3 h for incubation, much less than the 16 h needed with a customary latex agglutination test for SE detection such as a commercial test kit (SET-RPLA; Denka Seiken Co. Ltd., Tokyo, Japan). The rapid test was shown to be highly specific and sensitive for SE detection (detection limit, about 0.5 ng of SE per ml), comparable to the SET-RPLA test. The rapid test was also efficient in SE detection in foods and culture supernatants of staphylococcal strains, similar to the SET-RPLA test. This showed that a rapid test with high-density latex particles is fully reliable for use.
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Fujikawa et al. (1988) studied this question.
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