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Summary. As sialic acid is removed from red cells by neuraminidase treatment agglutinability measured by the sensitive AutoAnalyzer continuous flow technique increases with anti‐A, ‐B, ‐H, ‐D and ‐c. The increase in agglutinability is related to the amount of sialic acid removed, but the relationship is different for different antibodies. Rather than a simple non‐specific reduction in zeta potential, these results suggest a more complex explanation, probably involving the decrease of ordered water near the surface of the desialated cells.
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Greenwalt et al. (1973) studied this question.
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