Why the study?
To explore the immunomodulatory mechanism and optimal dose of dexmedetomidine for preventing postoperative cognitive dysfunction in elderly patients undergoing spinal surgery.
Does dexmedetomidine reduce postoperative cognitive dysfunction in elderly patients undergoing spinal surgery?
Does dexmedetomidine reduce postoperative cognitive dysfunction in elderly patients undergoing spinal surgery?
Dexmedetomidine may reduce postoperative cognitive dysfunction and inflammatory markers in elderly patients undergoing spinal surgery.
Supports DEX for POCD prevention in elderly spinal surgery patients; extends evidence on optimal dosing and immunomodulation.
OBJECTIVE: To explore the immunomodulatory mechanism and optimal dose of dexmedetomidine (DEX) for preventing postoperative cognitive dysfunction (POCD) in elderly patients undergoing spinal surgery. OBJECTIVE: ) after the operation, the cognitive function of the patients was assessed using the MMSE scale and their serum levels of β-amyloid (Aβ), TNF-α, IL-1β and IL-6 were measured. The occurrence of adverse effects including bradycardia and hypotension and the recovery time of the patients were recorded. OBJECTIVE: < 0.05). OBJECTIVE: , DEX can effectively reduce the incidence of POCD in elderly patients undergoing spinal surgery by inhibiting the production of Aβ and pro-inflammatory cytokines.
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A 2021 study studied this question.
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