Distinct Specificities of Inwardly Rectifying K+Channels for Phosphoinositides
Population
Inwardly rectifying K+ channels (Kir2.1/IRK1 and Kir3.1/3.4/GIRK1/GIRK4)
Design
Preclinical
Authors
Discussion
Loading...
Member takes
Implication
These specificities should not guide clinical ion channel modulation; leaves open selective targeting strategies in arrhythmia research.
Structured PICO
P
Population
Inwardly rectifying K+ channels (Kir2.1/IRK1 and Kir3.1/3.4/GIRK1/GIRK4)
I
Intervention
Various phosphoinositides (PtdIns(3,4)P2, PtdIns(3,5)P2, PtdIns(4,5)P2, PtdIns(3,4,5)P3) and synthetic analogs
O
Outcome
Channel activation efficacysurrogate
IRK1 and GIRK1/GIRK4 channels display distinct specificities for phosphoinositide head groups and acyl chains for their activation.
Cite This Study
Rohács et al. (1999) studied this question.