Why the study?
Does N-methylacetazolamide reduce the hypercapnic and hypoxic ventilatory response in anesthetized cats?
Population
Anesthetized cats
Comparison
N-methylacetazolamide 20 mg kg given intravenously vs Baseline (before infusion of NMA)
Design
Preclinical
Authors
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Indicates CA-independent sulfonamide effects on CO2 sensitivity; hypothesis-generating for human ventilatory control and requires further study.
Does N-methylacetazolamide reduce the hypercapnic and hypoxic ventilatory response in anesthetized cats?
N-methylacetazolamide, an acetazolamide analog without carbonic anhydrase inhibiting properties, reduces the hypercapnic ventilatory response, suggesting CA-independent effects of sulfonamides on ventilation control.
Teppema et al. (2015) studied this question.
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