In children and young adults with early restrictive eating disorders, mild QTc prolongation occurs in approximately 10% of patients but is not driven by electrolyte abnormalities or rate of weight loss.
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QTc prolongation in early restrictive eating disorders may warrant ECG monitoring independent of electrolytes; leaves open autonomic mechanisms for prospective confirmation.
UNLABELLED: Aim This study aimed to describe the frequency of QTc prolongation in children with restrictive eating disorders early in the course of disease admitted for inpatient therapy, to determine the frequency of associated ventricular arrhythmia, and to evaluate the relationship between QTc interval and concomitant electrolyte abnormalities and rate of weight loss. METHODS: This was a retrospective cohort study of patients aged 11-25 years with early restrictive eating disorders. RESULTS: In all, 82 patients met the inclusion criteria (84% female). In total, 9.8% had prolonged QTc interval during hospitalisation. Patients with prolonged QTc had significantly higher resting heart rates (p=0.006), but there was no association with hypokalaemia (p=0.31), hypomagnesaemia (p=0.43), hypophosphataemia (p=1), or rate of weight loss (p=1). CONCLUSION: Mild QTc prolongation in patients with restrictive eating disorders is not related to electrolyte abnormalities or rate of weight loss in this population, suggesting that investigation about other potential risk factors of prolonged QTc interval may be warranted.
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Guerrier et al. (2015) studied this question.
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