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Differentiating congenital from acquired LQTS guides pediatric management; Level 5 evidence leaves optimal screening open.
The QT interval is an electrocardiographic representation of ventricular depolarization and repolarization. A prolonged QT interval represents a prolonged action potential of ventricular myocytes and is mediated by an increase in inward current of sodium or calcium channels or a decrease in outward current through potassium channels. Initial assessments aim to differentiate congenital versus acquired long QT syndrome as subsequent investigation and management will differ based on the etiology of the QT prolongation.
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Cruz et al. (2023) studied this question.
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