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Supports troponin use in MI diagnosis; leaves open assay-specific threshold optimization in diverse populations.
The advent of the measurement of cardiac troponins, cardiac troponin T and cardiac troponin I, offered the clinician and the laboratory a new tool to detect myocar-dial injury in patients suspected of acute myocardial infarction (AMI). The new tests were both more sensitive and specific than the biomarkers they replaced due to their absolute specificity for myocardial injury. The ability to predict an adverse prognosis in patients previously consid-ered to have unstable angina and the ability to guide therapy led to their wide-spread adoption and ultimately to the redefinition of AMI to incorporate tropo-
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Paul Collinson (2014) studied this question.
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