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March 16, 2004Anaesthesia

Peri‐operative troponin I concentration as a marker of long‐term postoperative adverse cardiac outcomes – A study in high‐risk surgical patients

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Why the study?

Does peri-operative elevation of cardiac markers predict major adverse cardiac outcomes at 1 year in patients undergoing major vascular or joint surgery?

Population

157 patients undergoing major vascular surgery or major joint arthroplasty

Comparison

Elevated postoperative cardiac markers above the… vs Normal postoperative cardiac marker concentrations

Design

Cohort

Follow-up

1 year

Authors

HHHelen HighamJohn Radcliffe HospitalJSJohn W. SearSprint (United States)YSY. M. SEARJohn Radcliffe Hospital

Discussion

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Implication

Peri-operative troponin I and CK-MB elevations may aid 1-year MACE risk stratification after major surgery; leaves open whether targeted interventions improve outcomes.

Structured PICO

Does peri-operative elevation of cardiac markers predict major adverse cardiac outcomes at 1 year in patients undergoing major vascular or joint surgery?

P
Population
157 patients undergoing major vascular surgery or major joint arthroplasty
I
Intervention
Elevated postoperative cardiac markers (troponin I, troponin T, creatine kinase-MB) above the upper reference limit
C
Comparator
Normal postoperative cardiac marker concentrations
O
Outcome
Major adverse cardiac outcomes (composite of cardiac death, myocardial ischaemia, congestive cardiac failure, unstable angina, cerebrovascular accident and major arrhythmias needing active treatment) at 1 yearcomposite

Peri-operative elevation of troponin I and CK-MB are significant predictors of long-term major adverse cardiac outcomes in high-risk surgical patients.

Cite This Study

Higham et al. (2004) studied this question.

synapsesocial.com/papers/6a90ea217e3f32141373ca49https://doi.org/10.1111/j.1365-2044.2004.03660.x

Topics

Women and heart disease
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Diagnosis of Perioperative Myocardial Infarction with Measurement of Cardiac Troponin I1994 · 537 citations
  2. 2Beyond CK-MB1994 · 39 citations
  3. 3Independent Prognostic Value of Cardiac Troponin T in Patients With Confirmed Pulmonary Embolism2000 · 500 citations
  4. 4Increases in serum concentrations of cardiac proteins and the prediction of early postoperative cardiovascular complications in noncardiac surgery patients2000 · 53 citations
  5. 5Cardiac Troponin I Predicts Short-Term Mortality in Vascular Surgery Patients2002 · 310 citations