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April 1, 2003Journal of Cardiovascular Pharmacology

Characterization of Adrenoceptor Involvement in Skeletal and Cardiac Myotoxicity Induced by Sympathomimetic Agents: Toward a New Bioassay for β-blockers

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Population

Preclinical model (myocardium and soleus muscle) of isoproterenol-induced myotoxicity

Design

Preclinical

Authors

LTLip‐Bun TanLeeds General InfirmaryJBJatin G. BurnistonLiverpool John Moores UniversityWCWilliam ClarkEast Tennessee State University

Discussion

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Implication

May enable beta-AR subtype-specific bioassays in HF models; leaves open human translation and clinical relevance.

Structured PICO

P
Population
Preclinical model (myocardium and soleus muscle) of isoproterenol-induced myotoxicity
I
Intervention
Adrenoceptor modulators (clenbuterol, bupranolol, propranolol, bisoprolol, atenolol, ICI-118551, phenoxybenzamine, prazosin, yohimbine) and reserpine
O
Outcome
Extent of myocyte necrosis measured by antimyosin monoclonal antibody and quantitative methodssurrogate

The differential mediation of catecholamine-induced myotoxicity by beta1 and beta2 adrenoceptors in cardiac and skeletal muscle provides a potential new bioassay for evaluating beta-blockers in heart failure.

Cite This Study

Tan et al. (2003) studied this question.

synapsesocial.com/papers/6a90ebadc8472108f273c757https://doi.org/10.1097/00005344-200304000-00003
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Also Consider

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  1. 1Low- and high-level transgenic expression of β 2 -adrenergic receptors differentially affect cardiac hypertrophy and function in Gαq-overexpressing mice1999 · 231 citations
  2. 2Progressive ventricular remodeling in response to diffuse isoproterenol-induced myocardial necrosis in rats.1994 · 207 citations
  3. 3Circulating Cardiac Troponin I in Severe Congestive Heart Failure1997 · 398 citations
  4. 4Plasma Norepinephrine as a Guide to Prognosis in Patients with Chronic Congestive Heart Failure1984 · 3,142 citations
  5. 5β-Adrenergic receptor blockade arrests myocyte damage and preserves cardiac function in the transgenic Gsα mouse1999 · 121 citations