Effects of Trogopterorum Faeces on the Apoptostic Cell Death in Breast Cancer Cells

Effects of Trogopterorum Faeces on the Apoptostic Cell Death in Breast Cancer CellsYu-Rim Song, Ji-Eun Kim, Seung-Jeong YangKyung-Mi Park, Su-Jung Jung, Seong-Hee ChoDept. of Korean Gynecology and Obstetrics, College of Korean Medicine,Dong-Shin UniversityObjectives: This study was designed to investigate the effects of Trogopterorum Faeces on the apoptostic cell death in breast cancer cells. Methods: In the experiment, the effects of Trogopterorum Faeces on proliferation rates and type of cell death were investigated using MCF-7 cell s in vitro. The effects on expression levels of caspase 3 and caspase 9 were also inves tigated.Results: The effects on expression levels of caspase 3 and caspase 9 we re also investigated. In the present results, treatment with Trogopterorum Faeces decreased proliferation rates in a dose dependent manner. ID 50 (50 % inhibitory dosage) was 177.2 μg/ml. In addition, treatment with Trogopterorum Faeces increased percentage of apoptotic cells. Finally the expression level of caspase 3 and caspase 9 were elevated by treatment with Trogopterorum Faeces respectively. Conclusions: This study suggests that Trogopterorum Faeces can trigger caspase dependent apoptosis in MCF-7 cells.