January 1, 1986Thrombosis and Haemostasis

Adenosine Diphosphate (ADP)-Induced ⍺-Granules Release from Platelets of Native Whole Blood Is Reduced by Ticlopidine but Not by Aspirin or Dipyridamole

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Why the study?

Do aspirin, dipyridamole, or ticlopidine reduce ADP-induced alpha-granule release from platelets in native whole blood?

Population

Native whole blood

Design

Preclinical

Authors

VPVittorio PengoVascular Medicine MBM BoschelloUniversity of Padua AMA MarzariUniversity of Padua

Discussion

Member takes

Implication

Ticlopidine may selectively inhibit early platelet activation in animals; leaves open translation to human antiplatelet regimens.

Structured PICO

Do aspirin, dipyridamole, or ticlopidine reduce ADP-induced alpha-granule release from platelets in native whole blood?

Population

Native whole blood

Intervention

Aspirin (single 800 mg dose), dipyridamole (300 mg/day for 4 days), or ticlopidine (500 mg/day for 4 days)

Outcome

ADP-induced release of platelet alpha-granulessurrogate

Ticlopidine, unlike aspirin or dipyridamole, reduces ADP-induced platelet alpha-granule release, highlighting its specific mechanism in inhibiting early platelet activation.

Cite This Study

Pengo et al. (1986) studied this question.

synapsesocial.com/papers/6a90eecdefab70d99b73d362 https://doi.org/10.1055/s-0038-1661629

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Adenosine Diphosphate (ADP)-Induced ⍺-Granules Release from Platelets of Native Whole Blood Is Reduced by Ticlopidine but Not by Aspirin or Dipyridamole

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Adenosine Diphosphate (ADP)-Induced ⍺-Granules Release from Platelets of Native Whole Blood Is Reduced by Ticlopidine but Not by Aspirin or Dipyridamole

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider