Why the study?
Do anti-CD4 or anti-CD8 monoclonal antibodies prevent encephalitis in rats infected with Borna disease?
Do anti-CD4 or anti-CD8 monoclonal antibodies prevent encephalitis in rats infected with Borna disease?
Early treatment with anti-CD8 or anti-CD4 monoclonal antibodies prevents encephalitis in a rat model of Borna disease, highlighting the functional role of CD8+ cells in its pathogenesis.
Early anti-CD8 or anti-CD4 antibodies may limit brain inflammation in Borna disease rat models; leaves open CD8+ T-cell targeting in viral encephalitis.
Borna disease is a virus-induced, immunopathological encephalomyelitis in which CD4+ cells and macrophages dominate the pathological picture. However, significant numbers of CD8+ cells have been morphologically identified in perivascular infiltrates as well. To determine the contribution of different T-cell subsets to the pathogenesis of Borna disease, virus-infected rats were treated with monoclonal antibodies specific for CD4+ and CD8+ cells. Both types of monoclonal antibodies were able to significantly decrease or even prevent the local inflammatory reaction in the brain if given early during the infection. However, CD8-specific monoclonal antibodies appeared to be more effective than antibodies directed against CD4+ cells. Treatment initiated 4 days postinfection did not result in inhibition of encephalitis and disease. Virus titers in the brain of infected rats treated with T-cell-specific antibodies did not differ from titers in untreated infected control animals. The results indicate an important functional role of CD8+ cells, in addition to CD4+ cells, in the pathogenesis of Borna disease.
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Stitz et al. (1992) studied this question.
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