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No-reflow in PPCI tied to higher 30-day mortality; leaves open modifiable factors and targeted prevention strategies.
Background: Coronary artery disease (CAD) is the single most common cause of death in the developed world, responsible for about one in every six deaths; 15.5 million person's>20 years of age in the USA have coronary heart disease (CHD). No-reflow phenomenon defined classically as the lack of myocardial perfusion despite opening up the epicardial vessel in the setting of PPCI occurring in 10 % of cases of PPCI and associated with increase in 30 days mortality caused by multiple factors that lead to micro vascular obstruction and endothelial disruption by different mechanism like atherothrombotic embolization, ischemic injury, reperfusion injury and susceptibility of coronary microcirculation to injury.
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Tawfik et al. (2020) studied this question.
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