The time course of appearance of quickly reacting hemoglobin at pH 7 in dilute solutions (l10 µm in heme) was studied by means of a stopped flow-flash apparatus. When the flash is fired as soon as possible after the reaction of human deoxyhemoglobin with carbon monoxide or immediately after dilution of a concentrated human carbon monoxide hemoglobin solution, little of the quickly reacting form is present; the amount of quickly reacting material increases with time and reaches its final value in a few seconds. The results may be due to dissociation of ligand bound hemoglobin.
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Gibson et al. (1967) studied this question.
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