The direct ortho‐trifluoromethylation of arenes, including heteroarenes, with TMSCF3 has been accomplished by a copper(II)‐promoted CH activation reaction which completes within 30 minutes. Mechanistic investigations are consistent with the involvement of CH activation, rather than a simple electrophilic aromatic substitution (SEAr), as the key step.
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Shang et al. (2014) studied this question.
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