August 1, 1998Artificial OrgansOpen Access

In Vivo Evaluation of the Miniaturized Gyro Centrifugal Pump as an Implantable Ventricular Assist Device

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Population

Bovine model (calves), n=4

Design

Preclinical

Follow-up

23, 24, 40, and 50 days

Authors

YTYoshiyuki TakamiFujita Health University GOGoro OtsukaUniversity of Washington JMJurgen Mueller

Discussion

Member takes

Implication

Supports preclinical refinement of Gyro PI as VAD; leaves open human translation pending clinical trials.

Structured PICO

Population

Bovine model (calves), n=4

Intervention

Implantation of a plastic prototype miniaturized Gyro centrifugal pump (Gyro PI-601) as a left or right ventricular assist device (LVAD or RVAD), with heparin anticoagulation to maintain ACT 150-200 s

Outcome

Hemocompatibility and efficiency (including flow rates, input power, temperature, thrombus formation, renal/hepatic function, and plasma free hemoglobin)safety

In a bovine model, the miniaturized Gyro centrifugal pump demonstrated feasibility, adequate flow, and hemocompatibility as an implantable ventricular assist device.

Cite This Study

Takami et al. (1998) studied this question.

synapsesocial.com/papers/6a90f65f263aa8e25c73d00a https://doi.org/10.1046/j.1525-1594.1998.06021.x

Topics

Mechanical circulatory support

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In Vivo Evaluation of the Miniaturized Gyro Centrifugal Pump as an Implantable Ventricular Assist Device

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

In Vivo Evaluation of the Miniaturized Gyro Centrifugal Pump as an Implantable Ventricular Assist Device

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider