Why the study?
Does acute loss of metabolic control and its restoration by insulin affect endothelial function in type 1 diabetic patients?
Population
13 type 1 diabetic patients studied under conditions of mild ketosis, and 13 control subjects.
Comparison
Intravenous insulin infusion. vs Baseline conditions and healthy control subjects.
Design
Other
Authors
Loading...
Higher baseline flow and NO metabolites suggest endothelial dysfunction in type 1 diabetes; leaves open insulin's role in restoring function.
Does acute loss of metabolic control and its restoration by insulin affect endothelial function in type 1 diabetic patients?
Acute loss of metabolic control in type 1 diabetes is associated with endothelial dysfunction characterized by hyperemia and increased NO release, which is blunted upon restoration of metabolic control by insulin.
Avogaro et al. (1999) studied this question.